Abstract
A series of urea analogues related to SA6817 and a GSK phosphonic acid with reported ACE inhibitory activity were prepared and tested for dual ACE and ECE activities. Although excellent ACE and NEP inhibition was achieved, only modest ECE inhibition was observed with one analogue.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Angiotensin-Converting Enzyme Inhibitors / chemical synthesis
-
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
-
Aspartic Acid Endopeptidases / antagonists & inhibitors*
-
Aspartic Acid Endopeptidases / pharmacology*
-
Combinatorial Chemistry Techniques*
-
Endothelin-Converting Enzymes
-
Humans
-
Metalloendopeptidases / antagonists & inhibitors*
-
Metalloendopeptidases / pharmacology*
-
Molecular Structure
-
Naphthalenes / chemical synthesis
-
Naphthalenes / chemistry
-
Naphthalenes / pharmacology*
-
Stereoisomerism
-
Structure-Activity Relationship
-
Urea / analogs & derivatives*
-
Urea / chemical synthesis
-
Urea / chemistry
-
Urea / pharmacology*
Substances
-
Angiotensin-Converting Enzyme Inhibitors
-
Naphthalenes
-
SA6817
-
Urea
-
Aspartic Acid Endopeptidases
-
Metalloendopeptidases
-
Endothelin-Converting Enzymes